بحث بيانات أعضاء هيئة التدريس - جامعة الزقازيق

طارق محمد صلاح رشاد ابراهيم

الموقع الشخصى
السيرة الذاتية

طارق محمد صلاح رشاد ابراهيم

الكلية الصيدلة - القسم الكيمياء العضوية الصيدلية
الكيمياء العضويه

الدرجات العلمية

بكالوريوس فى الكيمياء العضويه, -جامعة الزقازيق [2000]
ماجستير فى الكيمياء العضويه, -جامعة الزقازيق [2007]
دكتوراه فى الكيمياء العضويه, -جامعة الزقازيق [2012]
(تشييد بعض المشتقات الحلقية الغير كيميائية الجديدة لدراستها بيولوجيا)

التدرج الوظيفى الأكاديمى

معيد : 26/11/2001
مدرس مساعد : 23/9/2007
مدرس : 27/3/2012
أستاذ مساعد : 29/5/2018
أستاذ : 31/10/2023

الأبحاث العلمية

1 - Synthesis of certain 1,2,3,-Benzotriazine Derivatives of Pharmaceutical Interest

2 - Chemical ligation of S-acylated cysteine peptides to form native peptides via 5-, 11-, and 14-membered cyclic transition states. (1432).

3 - Synthesis of Coumarin Conjugates of Biological Thiols for Fluorescent Detection and Estimation. (1432).

4 - Benzotriazole reagents for the syntheses of Fmoc, Boc and Alloc-Protected Amino Acids (1432).

5 - Design, synthesis, and biological activity of a novel series of 2,5-disubstituted furans/pyrroles as HIV-1 fusion inhibitors targeting gp41 (1432).

6 - Cysteinoyl- and Cysteine-containing Dipeptidoylbenzotriazoles with Free Sulfhydryl groups: (1433).

7 - Synthesis, molecular modeling and anti-inflammatory screening of new 1,2,3-Benzotriazinone Derivatives (1433).

8 - Efficient synthesis of N-acylbenzotriazoles using tosyl chloride: en route to suberoylanilide hydroxamic acid (SAHA). (1437).

9 - Benzotriazole-Mediated Synthesis and Antibacterial Activity of Novel N-Acylcephalexins. (1437).

10 - Green and Catalyst-Free Synthesis of Olsalazine Analogs (1437).

11 - Synthesis and Antiviral Bioassay of New Diphenyl Ether-based Compounds (1437).

12 - Synthesis and Anticancer Studies of Novel N-Benzyl pyridazinone Derivatives (1439).

13 - Synthesis, antibacterial properties and 2D-QSAR studies of quinolonetriazole conjugates (1439).

14 - Synthesis, Anticonvulsant Activity and Cytotoxicity of Novel Valproic Acid Derivatives (1438).

15 - Synthesis and Anticancer Studies of Novel N-Benzyl Pyridazinone Derivatives (1438).

16 - Novel benzenesulfonamide and 1,2-benzisothiazol-3(2H)-one-1,1-dioxide derivatives as potential selective COX-2 inhibitors (1440).

17 - Novel benzenesulfonamide and 1,2-benzisothiazol-3(2H)-one-1,1-dioxide derivatives as potential selective COX-2 inhibitors (1440).

18 - Design, synthesis, antimicrobial, and DNA gyrase inhibitory properties of fluoroquinolone-dichloroacetic acid hybrids. (1441).

19 - Design, synthesis, antimicrobial, and DNA gyrase inhibitory properties of fluoroquinolone-dichloroacetic acid hybrids. (1441).

20 - The Anticancer Activity for the Bumetanide-Based Analogs via Targeting the Tumor-Associated Membrane-Bound Human Carbonic Anhydrase-IX Enzyme (1442).

21 - Design, synthesis, and pharmacological evaluation of novel and selective COX-2 inhibitors based on bumetanide scaffold (1441).

22 - Design, synthesis and anticancer activity of novel valproic acid conjugates with improved histone deacetylase (HDAC) inhibitory activity (1441).

23 - Design and synthesis of novel pyrazolo[3,4-d]pyrimidin-4-one bearing quinoline scaffold as potent dual PDE5 inhibitors and apoptotic inducers for cancer therapy (1442).

24 - Potent Quinoline-Containing Combretastatin A-4 Analogues: Design, Synthesis, Antiproliferative, and Anti-Tubulin Activity (1442).

25 - N‑Acylbenzotriazole: convenient approach for protecting group‑free monoacylation of symmetric diamines (1441).

26 - Design, synthesis, antimicrobial, and DNA gyrase inhibitory properties of fluoroquinolone–dichloroacetic acid hybrids (1441).

27 - Design, synthesis and biological evaluation of novel 5-((substituted quinolin-3-yl/1-naphthyl) methylene)-3-substituted imidazolidin-2,4-dione as HIV-1 fusion inhibitors (1441).

28 - An Efficient Greener Approach for N-Acylation of Amines in Water Using Benzotriazole Chemistry (1441).

29 - In Vitro Antimycobacterial Activity and Physicochemical Characterization of Diaryl Ether Triclosan Analogues as Potential InhA Reductase Inhibitors (1441).

30 - Efficient Synthesis and Computational Studies of Useful Guanylating Agents: 1H-Benzotriazole-1-carboximidamides (1442).

31 - Repurposing anti-diabetic drug “Sitagliptin” as a novel virulence attenuating agent in Serratia marcescens (1441).

32 - Repurposing Anti-diabetic Drugs to Cripple Quorum Sensing in Pseudomonas aeruginosa (1442).

33 - Xylitol Inhibits Growth and Blocks Virulence in Serratia marcescens (1442).

34 - Novel 1,2,4-triazine-quinoline hybrids: The privileged scaffolds as potent multi-target inhibitors of LPS-induced inﬂammatory response via dual COX-2 and 15-LOX inhibition (1442).

35 - Alteration of Salmonella enterica Virulence and Host Pathogenesis through Targeting sdiA by Using the CRISPR-Cas9 System (1443).

36 - Uracil as a Zn-Binding Bioisostere of the Allergic Benzenesulfonamide in the Design of Quinoline–Uracil Hybrids as Anticancer Carbonic Anhydrase Inhibitors (1443).

37 - Novel Sunifiram-carbamate hybrids as potential dual acetylcholinesterase inhibitor and NMDAR coagonist: simulation-guided analogue design and pharmacological screening (1443).

38 - Uracil as a Zn-Binding Bioisostere of the Allergic Benzenesulfonamide in the Design of Quinoline–Uracil Hybrids as Anticancer Carbonic Anhydrase Inhibitors (1443).

39 - Design, Synthesis, In Vitro Anticancer Evaluation and Molecular Modelling Studies of 3,4,5-Trimethoxyphenyl-Based Derivatives as Dual EGFR/HDAC Hybrid Inhibitors (1443).

40 - New Multi-Targeted Antiproliferative Agents: Design and Synthesis of IC261-Based Oxindoles as Potential Tubulin, CK1 and EGFR Inhibitors (1443).

41 - Not Only Antimicrobial: Metronidazole Mitigates the Virulence of Proteus mirabilis Isolated from Macerated Diabetic Foot Ulcer (1442).

42 - Design, synthesis and pharmacological screening of novel renoprotective methionine-based peptidomimetics: Amelioration of cisplatin-induced nephrotoxicity (1442).

43 - New quinoline-triazole conjugates: Synthesis, and antiviral properties against SARS-CoV-2 (1442).

44 - Novel chalcone/aryl carboximidamide hybrids as potent anti-inflammatory via inhibition of prostaglandin E2 and inducible NO synthase activities: design, synthesis, molecular docking studies and ADMET prediction (1442).

45 - Novel 1,2,4-triazine-quinoline hybrids: The privileged scaffolds as potent multi-target inhibitors of LPS-induced inflammatory response via dual COX-2 and 15-LOX inhibition (1442).

46 - Novel 1,2,4-oxadiazole-chalcone/oxime hybrids as potential antibacterial DNA gyrase inhibitors: Design, synthesis, ADMET prediction and molecular docking study (1442).

47 - Discovery of novel quinoline-based analogues of combretastatin A-4 as tubulin polymerisation inhibitors with apoptosis inducing activity and potent anticancer effect (1442).

48 - Efficient Synthesis and Computational Studies of Useful Guanylating Agents: 1H-Benzotriazole-1-carboximidamides (1442).

49 - N‑Acylbenzotriazole: convenient approach for protecting group‑free monoacylation of symmetric diamines (1441).

50 - Potential repurposed SARS-CoV-2 (COVID-19) infection drugs (1442).

51 - Fluoroquinolone-3-carboxamide Amino Acid Conjugates: Synthesis, Antibacterial Properties And Molecular Modeling Studies (1442).

52 - Controlling of Bacterial Virulence: Evaluation of Anti-Virulence Activities of Prazosin against Salmonella enterica (1444).

53 - Hiring of the Anti-Quorum Sensing Activities of Hypoglycemic Agent Linagliptin to Alleviate the Pseudomonas aeruginosa Pathogenesis (1444).

54 - Sodium Citrate Alleviates Virulence in Pseudomonas aeruginosa (1443).

55 - Anti-Quorum Sensing Activities of Gliptins against Pseudomonas aeruginosa and Staphylococcus aureus (1443).

56 - Human dihydrofolate reductase inhibition effect of 1-Phenylpyrazolo [3,4–d]pyrimidines: Synthesis, antitumor evaluation and molecular modeling study (1444).

57 - Design, synthesis and antitumor evaluation of novel pyrazolo[3,4-d]pyrimidines incorporating different amino acid conjugates as potential DHFR inhibitors (1444).

58 - Development of Isatin-Based Schiff Bases Targeting VEGFR-2 Inhibition: Synthesis, Characterization, Antiproliferative Properties, and QSAR Studies (1443).

59 - Schiff bases as linker in the development of quinoline-sulfonamide hybrids as selective cancer-associated carbonic anhydrase isoforms IX/XII inhibitors: A new regioisomerism tactic (1444).

60 - Drug repositioning: doxazosin attenuates the virulence factors and biofilm formation in Gram-negative bacteria (1444).

61 - Synergistic Benefits: Exploring the Anti-Virulence Effects of Metformin/Vildagliptin Antidiabetic Combination against Pseudomonas aeruginosa via Controlling Quorum Sensing Systems (1444).

62 - Exploitation of multi-walled carbon nanotubes/ Cu(II)-metal organic framework based glassy carbon electrode for the determination of orphenadrine citrate (1445).

63 - Cilostazol is a promising anti-pseudomonal virulence drug by disruption of quorum sensing (1446).

64 - Redirecting pantoprazole as a metallo-beta-lactamase inhibitor in carbapenem-resistant Klebsiella pneumoniae (1445).

65 - Exploitation of novel pyrazolo[3,4-d]pyrimidine scaffold tethered to thiazole as potential EGFR/HER2 dual kinase inhibitor to overcome lapatinib resistant breast cancer: Design, synthesis, in silico docking and molecular dynamic simulation (1446).

المجالات البحثية