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Curriculum Vitae

Osama Ibrahim Abdou Elsabagh

Faculty pharmacy - Department Medicinal Chemistry Department

BSc In NULL, [1981]
MSc In NULL, [1987]
PhD In NULL, [1995]

Academic Jobs

معيد : 15/12/1981
Doctor Assisant : 18/3/1987
Doctor : 18/4/1995
Professor Assisant : 28/9/2004
Professor : 27/10/2009

Publications

1 - Design, synthesis and antitumor evaluation of novel pyrazolo[3,4-d]pyrimidines incorporating different amino acid conjugates as potential DHFR inhibitors (2022).

2 - Synthesis of Some New Benzisothiazolone and Benzenesulfonamide Derivatives of Biological Interest Starting from Saccharin Sodium (2013).

3 - Synthesis and Biological Evaluation of Some N-Arylpyrazoles and Pyrazolo[3,4-d]pyridazines as Anti-Inflammatory Agents (2013).

4 - Synthesis of new benzotriazepin-5(2H)-one derivatives of expected antipsychotic activity (2012).

5 - Synthesis and pharmacological studies for some new benzotriazole and dibenzodiazepine derivatives as antipsychotic agents (2009).

6 - Synthesis and antiviral activity of new pyrazole and thiazole derivatives (2009).

7 - Synthesis of new acridines and hydrazones derived from cyclic β-diketone for cytotoxic and antiviral evaluation (2009).

8 - Synthesis of new 2(1H)-quinoxalinone derivatives for antimicrobial and antiinflammatory evaluation (2009).

9 - Design, synthesis and cytotoxic activity of novel 1-aroyl -4- (2- chloroethyl) semicarbazides (2007).

10 - Exploitation of novel pyrazolo[3,4-d]pyrimidine scaffold tethered to thiazole as potential EGFR/HER2 dual kinase inhibitor to overcome lapatinib resistant breast cancer: Design, synthesis, in silico docking and molecular dynamic simulation (2025).

11 - Design, Synthesis and Evaluation of Novel Inhibitors of E2 Ubiquitin Conjugating Enzyme as Potential Breast Cancer Therapeutics (2024).

12 - Synthesis and biological screening of new quinazolin-4(3H)-one and benzotriazepine derivatives (2024).

13 - Design, synthesis, and pharmacological evaluation of novel and selective COX-2 inhibitors based on bumetanide scaffold (2020).

14 - The Anticancer Activity for the Bumetanide-Based Analogs via Targeting the Tumor-Associated Membrane-Bound Human Carbonic Anhydrase-IX Enzyme (2020).

15 - Pioneering 1,3,5-triaryl pyrazolines as promising dual inhibitors of COX-2 and 15-LOX endowed with potent anticancer activity: design, synthesis, and in silico stud (2025).

16 - Human dihydrofolate reductase inhibition effect of 1-Phenylpyrazolo [3,4–d]pyrimidines: Synthesis, antitumor evaluation and molecular modeling study (2022).

17 - Synthesis of new multitarget-directed ligands containing thienopyrimidine nucleus for inhibition of 15-lipoxygenase, cyclooxygenases, and pro-inflammatory cytokines (2023).

Research Area