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Curriculum Vitae

Zakareyah Kamel Abdelsamie

Faculty pharmacy - Department Pharmaceutical Organic Chemistry Department

Scientific degrees

BSc In NULL, [1980]
MSc In NULL, [1984]
( pharmacutical organic chemistry)
PhD In NULL, [1987]
(لا يوجد)

الحالة الوظيفية الحالية :

قائم بالعمل

Academic Jobs

معيد : 23/8/1980
Doctor Assisant : 22/2/1984
Doctor : 19/8/1987
Professor Assisant : 14/1/1992
Professor : 28/7/1998
Professor Emeritus : 1/1/2019

Publications

1 - Regioselective hydroxysulphenylation of derivatives of allylic alcohols and amines. (1986).

2 - New routes to heterocycles via sulphenylation of unsaturated amides (1987).

3 - Trifluoroacetoxysulphenylation of unsaturated nitriles as a route to lactones (1986).

4 - Synthesis of certain s-triazolo[3,4-b]-1,3,4-thiadiazole derivatives of pharmaceutical interest (1987).

5 - Synthesis and biological activity of some novel triazolothiadiazines (1988).

6 - Regioselective synthesis of hydroxy sulphides via trifluoroacetoxy sulphenylation of derivatives of allylic alcohols (1988).

7 - New routes to heterocycles via sulphenylation of unsaturated amides (1988).

8 - Trifluoroacetoxysulphenylation of unsaturated nitriles and transformation of the adducts into lactones (1988).

9 - Synthesis of 1,2,4-triazolo and 1,2,4-triazolo[3,4-b]thiadiazinone derivatives as potential antiinflammatory agents (1990).

10 - Zurkany. Synthesis and biological activity of new 2-(5-mercapto- 1,3,4-oxadiazol-2- ylmethyl)-4-benzyl-l-(2H)-phthalazinone derivatives (1990).

11 - Synthesis of some novel s-triazolo[3,4-b]-1,3,4-thiadiazole derivatives as antiinflammatory agents (1990).

12 - Phthalazine derivatives from 1-hydrazino-4-benzyl (or methyl) phthalazine (1990).

13 - Synthesis of some novel dibenzo[c,f][2,7]naphthyridine derivatives as possible antitumor agents (1990).

14 - Synthesis of 1,2,4-triazolo[3,4-b]-thiadiazinone derivatives as potential anti-inflammatory agents (1990).

15 - anticonvulsantl properties of some novel quinazolone-thiosemicarbazone and 4-thiazolidone derivatives (1991).

16 - Regioselective hydroxysulphenylalion of butadiene using different metal ions (1991).

17 - Antiinflammatory activity of some novel s-triazole derivatives (1991).

18 - Synthesis and anti-inflammatory activity of some novel 1,3,4-oxadiazole derivatives (1991).

19 - Reaction of 2-amino-4,5,6,7,-tetrahydrobenzo[b]thiophen-3-carboxylic acid with substituted ureas and thioureas (1991).

20 - New synthesis of pyridopyrimidine and pyridotetrahyroquinoline derivatives (1991).

21 - Synthesis and antibacterial activity of of some 1,3,4,-oxadiazoles (1991).

22 - Thieno[2,3-d]pyrimidines as potential antimicrobial agents (1993).

23 - Synthesis and anti-inflammatory of some quinazolinone derivatives fused with triazole and thiadiazole rings (1993).

24 - . Syntesis and biological activity of novel quinazolinones derived from 2-hydrazino-3-phenyl-4(3H)- quinazolinone (1993).

25 - Synthesis of some novel 2(lH)-quinazolinones and 2-thioxo analogues from newly synthesized l-acyl-3-alkoxyphenylureas and thioureas (1993).

26 - Synthesis and central nervous system activity of some novel 4(3H)-quinazolinones including thiazolo[3,2-b]-s-triazoles (1993).

27 - Synthesis and anti-hypertensive evaluation of some phthalazines containing 1,3,4-thiadiazines and 1,3,4-thiadiazin-5-ones. (1993).

28 - Synthesis and antibacterial activity of novel benzothiazole, benzimidazole, imidazolidine and imidazo-[2,1-b]-1,3,4-thiadiazole derivatives (1994).

29 - Polyfused heterocyclic systems derived from 4-amino-3-aryloxymethyl-5-mercapto-5-triazoles (1994).

30 - Synthesis of some new 3-mercapto-5-substituted-l,2,4-triazine-s-triazoles for evaluation as antimicrobial agents (1994).

31 - Nucleophilic substitution and ring closure reactions of (5,6-diphenyl-1,2,4-triazin-3-yl)oxyacetohydrazide with bielectrophiles (1994).

32 - Synthesis and antiinflammatory properties of some novel thiazolidinones and imidazolidinones derived from 4-(3-phenyl-4(3H)-quinazolinon-2yl)-3-thiosemicarbazone (1995).

33 - Sulfenocyclization of unsaturated ureas and thioureas (1995).

34 - Synthesis and antihypertensive activity of novel l-(4-benzyl-l -phthalazinyl)pyrazolo[3,4-d] pyrimidines. (1996).

35 - Synthesis and antifungal activity of some imidazo, pyrazino and v-triazoloquinoxalines (1997).

36 - Synthesis and antiinflammatory activity of novel pyrimidine derivatives (1997).

37 - Utility of 2-hydrazino-4,6-dimethylpyrimidine in heterocyclic synthesis (1997).

38 - One pot synthesis of 2(1H)-quinazolinone derivatives (1997).

39 - Review article in “Chemistry of azolopyrimidines as purine analogs (2001).

40 - Synthesis and anti-inflammatory activity of novel thienopyrimidine derivatives (2004).

41 - Synthesis and anti-inflammatory activity of some novel quinazoline derivatives (2006).

42 - Synthesis and anti-inflammatory activity of novel pyrazole derivatives (2007).

43 - Design, synthesis and molecular modeling study of quinazolinones with potential anti-inflammatory activity (2009).

44 - Selective Synthesis and Structural Elucidation of S-Acyl- and N-Acylcysteines (2009).

45 - Efficient Synthesis of Azo Dye Labeled Terpenes, Sugars, and Steroids Usin N-(4-Arylazobenzoyl)-1H-benzotriazoles (2009).

46 - An efficient method for the preparation of peptide alcohols (2009).

47 - The chemical ligation of selectively S-acylated cysteinepeptides to form native peptides via 5-, 11- and 14-membered cyclic transition states (2010).

48 - Fluorescent Detection and Estimation of Biological Thiols (2011).

49 - Benzotriazole reagents for the syntheses of Fmoc, Boc and Alloc-Protected Amino Acids (2011).

50 - Cysteinoyl- and Cysteine-containing Dipeptidoyl benzotriazoles with Free Sulfhydryl groups: Easy Access to N-terminal and internal Cysteine Peptides (2012).

51 - Synthesis, molecular modeling and anti-inflammatory screening of new 1,2,3-Benzotriazinone Derivatives (2012).

52 - Palladium-Catalyzed Synthesis of Substituted Pyrido[2,3-d]pyridazines at Positions 5 and 8 (2012).

53 - Design, synthesis, and molecular modeling of pyridazinone and phthalazinone derivatives as protein kinases inhibitors (2013).

54 - DOCKING, SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL PYRAZOLINE DERIVATIVES AS POTENTIAL ANTIMICROBIAL AND ANTITUMOR AGENTS (2016).

55 - SYNTHESIS, ANTI-INFLAMMATORY AND ANTIMICROBIAL EVALUATION OF NICOTINAMIDES BEARING THIAZOLE AND PYRAZOLINE PHARMACOPHORES (2017).

56 - Synthesis, Anticonvulsant Activity and Cytotoxicity of Novel Valproic Acid Derivatives (2017).

57 - Design, synthesis and anticancer activity of novel valproic acid conjugates with improved histone deacetylase (HDAC) inhibitory activity (2020).

58 - Design and synthesis of novel pyrazolo[3,4-d]pyrimidin-4-one bearing quinoline scaffold as potent dual PDE5 inhibitors and apoptotic inducers for cancer therapy (2020).

59 - Potent Quinoline-Containing Combretastatin A-4 Analogues: Design, Synthesis, Antiproliferative, and Anti-Tubulin Activity (2020).

60 - N‑Acylbenzotriazole: convenient approach for protecting group‑free monoacylation of symmetric diamines (2020).

61 - Design, synthesis, antimicrobial, and DNA gyrase inhibitory properties of fluoroquinolone–dichloroacetic acid hybrids (2020).

62 - An Efficient Greener Approach for N-Acylation of Amines in Water Using Benzotriazole Chemistry (2020).

63 - Design, Synthesis and Pharmacological Screening of Novel Renoprotective Methionine-based Peptidomimetics: Amelioration of Cisplatin-induced nephrotoxicity (2021).

64 - Discovery of Novel Quinoline-Based Analogues of Combretastatin A-4 as Tubulin Polymerization Inhibitors with Apoptosis Inducing Activity and Potent Anticancer Effect (2021).

65 - Development of Isatin-Based Schiff Bases Targeting VEGFR-2 Inhibition: Synthesis, Characterization, Antiproliferative Properties, and QSAR Studies (2022).

66 - Synthesis of imidazolidine‐2,4‐dione and 2‐thioxoimidazolidin‐4‐one derivatives as inhibitors of virulence factors production in Pseudomonas aeruginosa (2020).

Research Area

الكيمياء العضوية الصيدلية