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Amr Selim Ahmed Ali Abu Lila
Faculty pharmacy - Department Pharmaceutics Department
NULL
Scientific degrees
BSc In NULL, [2000]
MSc In NULL, [2005]
PhD In NULL, [2010]
الحالة الوظيفية الحالية :
معار
Academic Jobs
معيد : 5/10/2000
Doctor Assisant : 13/3/2005
Doctor : 26/10/2010
Professor Assisant : 26/1/2016
Professor : 23/2/2021
Publications
1 -
Pharmaceutical Studies of Interactions Between Certain AntiHypertensive Drugs and Plasma Components or Their Substitutes.
2 -
Abrogation of the accelerated blood clearance phenomenon by SOXL regimen: promise for clinical application (2013).
3 -
Use of polyglycerol (PG), instead of polyethylene glycol (PEG), prevents induction of the accelerated blood clearance phenomenon against long-circulating liposomes upon repeated administration (2013).
4 -
The co-delivery of oxaliplatin abrogates the immunogenic response to PEGylated siRNA-lipoplex (2013).
5 -
The accelerated blood clearance (ABC) phenomenon: clinical challenge and approaches to manage (2013).
6 -
Ex-vivo/in-vitro anti-polyethylene glycol (PEG) immunoglobulin M production from murine splenic B cells stimulated by PEGylated liposome (2013).
7 -
Selective delivery of oxaliplatin to tumor tissue by nanocarrier system enhances overall therapeutic efficacy of the encapsulated oxaliplatin (2014).
8 -
Multiple administration of PEG-coated liposomal oxaliplatin enhances its therapeutic efficacy: a possible mechanism and the potential for clinical application (2012).
9 -
Tumor-type-dependent vascular permeability constitutes a potential impediment to the therapeutic efficacy of liposomal oxaliplatin (2012).
10 -
Combination therapy with metronomic S-1 dosing and oxaliplatin-containing PEG-coated cationic liposomes in a murine colorectal tumor model: synergy or antagonism? (2012).
11 -
A double-modulation strategy in cancer treatment with a chemotherapeutic agent and siRNA (2011).
12 -
Application of Polyglycerol Coating to Plasmid DNA Lipoplex for the Evasion of the Accelerated Blood Clearance Phenomenon in Nucleic Acid Delivery (2014).
13 -
Sequential treatment of oxaliplatin-containing PEGylated liposome together with S-1 improves intratumor distribution of subsequent doses of oxaliplatin-containing PEGylated liposome (2014).
14 -
B cell-intrinsic toll-like receptor 7 is responsible for the enhanced anti-PEG IgM production following injection of siRNA-containing PEGylated lipoplex in mice (2014).
15 -
Generation, characterization and in vivo biological activity of two distinct monoclonal anti-PEG IgMs (2014).
16 -
Improved intratumoral delivery of PEG-coated siRNA-lipoplexes by combination with metronomic S-1 dosing in a murine solid tumor model (2012).
17 -
Targeting Anticancer Drugs to Tumor Vasculature Using Cationic Liposomes (2010).
18 -
Sequential administration with oxaliplatin-containing PEG-coated cationic liposomes promotes a significant delivery of subsequent dose into murine solid tumor (2010).
19 -
Recent advances in tumor vasculature targeting using liposomal drug delivery systems (2009).
20 -
Oxaliplatin targeting to angiogenic vessels by PEGylated cationic liposomes suppresses the angiogenesis in a dorsal air sac mouse model (2009).
21 -
Oxaliplatin encapsulated in PEG-coated cationic liposomes induces significant tumor growth suppression via a dual-targeting approach in a murine solid tumor model (2009).
22 -
Activation of TLR9 by incorporated pDNA within PEG-coated lipoplex enhances anti-PEG IgM production (2014).
23 -
Relationship between the Concentration of Anti-polyethylene Glycol (PEG) Immunoglobulin M (IgM) and the Intensity of the Accelerated Blood Clearance (ABC) Phenomenon against PEGylated Liposomes in Mice (2015).
24 -
Advanced therapeutic approach for the treatment of malignant pleural mesothelioma via the intrapleural administration of liposomal pemetrexed (2015).
25 -
Intra-tumor distribution of PEGylated liposome upon repeated injection: No possession by prior dose (2015).
26 -
Encapsulation in a rapid-release liposomal formulation enhances the anti-tumor efficacy of pemetrexed in a murine solid mesothelioma-xenograft model (2016).
27 -
Downregulation of thymidylate synthase by RNAi molecules enhances the antitumor effect of pemetrexed in an orthotopic malignant mesothelioma xenograft mouse model (2016).
28 -
Improvement of intratumor microdistribution of PEG ylated liposome via tumor priming by metronomic S-1 dosing (2016).
29 -
Systemically Administered RNAi Molecule Sensitizes Malignant Pleural Mesotheliomal Cells to Pemetrexed Therapy (2016).
30 -
Ganglioside inserted into PEGylated liposome attenuates anti-PEG immunity (2017).
31 -
Liposomal Delivery Systems: Design Optimization and Current Applications (2017).
32 -
Co-administration of liposomal l-OHP and PEGylated TS shRNA-lipoplex: A novel approach to enhance anti-tumor efficacy and reduce the immunogenic response to RNAi molecules (2017).
33 -
Metronomic chemotherapy and nanocarrier platforms (2017).
34 -
Metronomic S-1 dosing and thymidylate synthase silencing have synergistic antitumor efficacy in a colorectal cancer xenograft model (2017).
35 -
Modulation of antitumor immunity contributes to the enhanced therapeutic efficacy of liposomal oxaliplatin in mouse model (2017).
36 -
Preparation and characterization of intravaginal vardenafil suppositories targeting a complementary treatment to boost in vitro fertilization process (2018).
37 -
Fast disintegrating tablet of Valsartan for the treatment of pediatric hypertension: In vitro and in vivo evaluation (2018).
38 -
Liposomal Nanomedicine (2014).
39 -
Anti-PEG IgM production via a PEGylated nano-carrier system for nucleic acid delivery (2013).
40 -
Reactivity of IgM antibodies elicited by PEGylated liposomes or PEGylated lipoplexes against auto and foreign antigens (2018).
41 -
Cationic liposomes and tumor vasculature targeting: A therapeutic approach that has potential for solid tumors (2011).
42 -
Intratumoral Visualization of Oxaliplatin within a Liposomal Formulation Using X‑ray Fluorescence Spectrometry (2018).
43 -
A hydroxyl PEG version of PEGylated liposomes and its impact on anti-PEG IgM induction and on the accelerated clearance of PEGylated liposomes (2018).
44 -
A Novel Strategy to Increase the Yield of Exosomes (Extracellular Vesicles) for an Expansion of Basic Research (2018).
45 -
Doxorubicin Expands in Vivo Secretion of Circulating Exosome in Mice (2018).
46 -
Design, in vitro/in vivo evaluation of meclizine HCl-loaded floating microspheres targeting pregnancy-related nausea and vomiting (2018).
47 -
Immune Response to PEGylated Nanomedicines: Impact of IgM Response (2018).
48 -
Liposome co-incubation with cancer cells secreted exosomes (extracellular vesicles) with different proteins expressions and different uptake pathways (2018).
49 -
A Cell Assay for Detecting Anti-PEG Immune Response against PEG-Modified Therapeutics (2018).
50 -
Liposome co-incubation with cancer cells secreted exosomes (extracellular vesicles) with different proteins expressions and different uptake pathways. (2018).
51 -
A Novel Platform for Cancer Vaccines: Antigen-Selective Delivery to Splenic Marginal Zone B Cells via Repeated Injections of PEGylated Liposomes (2018).
52 -
PEGylation and anti-PEG antibodies (2018).
53 -
Anti-PEG IgM Production via a PEGylated Nanocarrier System for Nucleic Acid Delivery (2019).
54 -
A simplified method for manufacturing RNAi therapeutics for local administration (2019).
55 -
PEGylated liposomes: immunological responses (2019).
56 -
Cancer cell-type tropism is one of crucial determinants for the efficient systemic delivery of cancer cell-derived exosomes to tumor tissues (2019).
57 -
"Immunological responses to PEGylated proteins: anti-PEG antibodies" (2019).
58 -
Pegfilgrastim (PEG-G-CSF) Induces Anti-polyethylene Glycol (PEG) IgM via a T Cell-Dependent Mechanism (2020).
59 -
A Unique Gene-Silencing Approach, Using an Intelligent RNA Expression Device (iRed), Results in Minimal Immune Stimulation When Given by Local Intrapleural Injection in Malignant Pleural Mesothelioma (2020).
60 -
Adjuvant Antitumor Immunity Contributes to the Overall Antitumor Effect of Pegylated Liposomal Doxorubicin (Doxil®) in C26 Tumor-Bearing Immunocompetent Mice (2020).
61 -
Development and optimization of dual drug-loaded nanoparticles for the potent anticancer effect on renal carcinoma (2020).
62 -
Impact of Pre-Existing or Induced Anti-PEG IgM on the Pharmacokinetics of Peginterferon Alfa-2a (Pegasys) in Mice (2020).
63 -
Pegfilgrastim (PEG-G-CSF) induces anti-PEG IgM in a dose dependent manner and causes the accelerated blood clearance (ABC) phenomenon upon repeated administration in mice (2020).
64 -
Hepatosplenic phagocytic cells indirectly contribute to anti-PEG IgM production in the accelerated blood clearance (ABC) phenomenon against PEGylated liposomes: Appearance of an unexplained mechanism in the ABC phenomenon (2020).
65 -
Treatment of pulmonary arterial hypertension by vardenafil-solid dispersion lozenges as a potential alternative drug delivery system (2020).
66 -
Complement activation induced by PEG enhances humoral immune responses against antigens encapsulated in PEG-modified liposomes (2021).
67 -
Anti-PEG IgM production and accelerated blood clearance phenomenon after the administration of PEGylated exosomes in mice (2021).
68 -
Enhanced Cytotoxic Activity of Docetaxel-Loaded Silk Fibroin Nanoparticles against Breast Cancer Cells (2021).
69 -
Ghatti gum-base graft copolymer: a plausible platform for pH-controlled delivery of antidiabetic drugs (2021).
70 -
Synthesis of Gold Nanoparticles by Using Green Machinery: Characterization and In Vitro Toxicity (2021).
71 -
Pulmonary Targeting of Inhalable Moxifloxacin Microspheres for Effective Management of Tuberculosis (2021).
72 -
Doxorubicin Embedded into Nanofibrillated Bacterial Cellulose (NFBC) Produces a Promising Therapeutic Outcome for Peritoneally Metastatic Gastric Cancer in Mice Models via Intraperitoneal Direct Injection (2021).
73 -
Efficacy of SPG-ODN 1826 Nanovehicles in Inducing M1 Phenotype through TLR-9 Activation in Murine Alveolar J774A.1 Cells: Plausible Nano-Immunotherapy for Lung Carcinoma (2021).
74 -
Not Only Antimicrobial: Metronidazole Mitigates the Virulence of Proteus mirabilis Isolated from Macerated Diabetic Foot Ulcer (2021).
75 -
Folic acid-conjugated raloxifene-loaded graphene-based nanocarrier: Fabrication, characterization and antitumor screening (2021).
76 -
Formulation, characterization, and cellular toxicity assessment of tamoxifen-loaded silk fibroin nanoparticles in breast cancer (2021).
77 -
Preparation, characterization and evaluation of anti-inflammatory and anti-nociceptive effects of brucine-loaded nanoemulgel (2021).
78 -
Tamoxifen-loaded functionalized graphene nanoribbons for breast cancer therapy (2021).
79 -
Alteration of Salmonella enterica Virulence and Host Pathogenesis through Targeting sdiA by Using the CRISPR-Cas9 System (2021).
80 -
Brucine‑Loaded Ethosomal Gel: Design, Optimization, and Anti‑inflammatory Activity (2021).
81 -
Quality by Design for Optimizing a Novel Liposomal Jojoba Oil-Based Emulgel to Ameliorate the Anti-Inflammatory Effect of Brucine (2021).
82 -
Design, synthesis and cytotoxic evaluation of 2-amino-4- aryl-6-substituted pyridine-3,5-dicarbonitrile derivatives (2021).
83 -
I.p.-injected cationic liposomes are retained and accumulate in peritoneally disseminated tumors (2022).
84 -
Preparation, characterization and evaluation of anti-inflammatory and anti-nociceptive effects of brucine-loaded nanoemulgel (2021).
85 -
Alteration of Salmonella enterica Virulence and Host Pathogenesis through Targeting sdiA by Using the CRISPR-Cas9 System (2021).
86 -
A mouse model for studying the effect of blood anti-PEG IgMs levels on the in vivo fate of PEGylated liposomes (2022).
87 -
Development and Evaluation of Clove and Cinnamon Supercritical Fluid Extracts-Loaded Emulgel for Antifungal Activity in Denture Stomatitis (2022).
88 -
Cefotaxime Mediated Synthesis of Gold Nanoparticles: Characterization and Antibacterial Activity (2022).
89 -
Pulmonary Targeting of Levofloxacin Using Microsphere-Based Dry Powder Inhalation (2022).
90 -
Preparation and Characterization of a Novel Mucoadhesive Carvedilol Nanosponge: A Promising Platform for Buccal Anti-Hypertensive Delivery (2022).
91 -
Enhancement of Vancomycin Potential against Pathogenic Bacterial Strains via Gold Nano-Formulations: A Nano-Antibiotic Approach (2022).
92 -
Experimental Design and Optimization of Nano-Transfersomal Gel to Enhance the Hypoglycemic Activity of Silymarin (2022).
93 -
Screening of Apoptosis Pathway-Mediated Anti-Proliferative Activity of the Phytochemical Compound Furanodienone against Human Non-Small Lung Cancer A-549 Cells (2022).
94 -
Poly "-Carpolactone Nanoparticles for Sustained Intra-Articular Immune Modulation in Adjuvant-Induced Arthritis Rodent Model (2022).
95 -
Anti-ulcer properties, cytokines, and apoptosis regulatory effects of Olea europaea leaves from Hail Province, Saudi Arabia (2022).
96 -
Bioactive principles, anti-diabetic, and anti-ulcer activities of Ducrosia anethifolia Boiss leaves from the Hail region, Saudi Arabia (2022).
97 -
Biosynthesis of Silver Nanoparticles Using Commiphora mukul Extract: Evaluation of Anti-Arthritic Activity in Adjuvant-Induced Arthritis Rat Model (2022).
98 -
Cytotoxic and Apoptotic Effect of Rubus chingii Leaf Extract against Non-Small Cell Lung Carcinoma A549 Cells (2022).
99 -
Delafloxacin-Capped Gold Nanoparticles (DFX-AuNPs): An Effective Antibacterial Nano-Formulation of Fluoroquinolone Antibiotic (2022).
100 -
Ginger Extract-Loaded Sesame Oil-Based Niosomal Emulgel: Quality by Design to Ameliorate Anti-Inflammatory Activity (2022).
101 -
Gold Nanoparticle-Based Resuscitation of Cefoxitin against Clinical Pathogens: A Nano-Antibiotic Strategy to Overcome Resistance (2022).
102 -
Inflammation targeted nanomedicines: Patents and applications in cancer therapy (2022).
103 -
Manganese chloride (MnCl2) induced novel model of Parkinson’s disease in adult Zebrafish; Involvement of oxidative stress, neuroinflammation and apoptosis pathway (2022).
104 -
Phytosomes as a Plausible Nano-Delivery System for Enhanced Oral Bioavailability and Improved Hepatoprotective Activity of Silymarin (2022).
105 -
Spectral Analysis and Antiulcer Potential of Lactuca sativa through the Amelioration of Proinflammatory Cytokines and Apoptosis Markers (2022).
106 -
Vardenafil-Loaded BilosomalMucoadhesive Sponge for Buccal Delivery: Optimization, Characterization, and In Vivo Evaluation (2022).
107 -
Ginger Extract-Loaded Sesame Oil-Based Niosomal Emulgel: Quality by Design to Ameliorate Anti-Inflammatory Activity (2022).
108 -
Antibiotic-Loaded Gold Nanoparticles: A Nano-Arsenal against ESBL Producer-Resistant Pathogens (2023).
109 -
Biofilm Lifestyle in Recurrent Urinary Tract Infections (2023).
110 -
Clinical Resistant Strains of Enterococci and Their Correlation to Reduced Susceptibility to Biocides: Phenotypic and Genotypic Analysis of Macrolides, Lincosamides, and Streptogramins (2023).
111 -
Coleus aromaticus Ethanolic Leaves Mediate Inhibition of NF-B Signaling Pathway in Lung Adenocarcinoma A549 Cells (2023).
112 -
Development and Characterization of Pullulan-Based Orodispersible Films of Iron (2023).
113 -
Ganetespib with Methotrexate Acts Synergistically to Impede NF-κB/p65 Signaling in Human Lung Cancer A549 Cells (2023).
114 -
Nano-Conversion of Ineffective Cephalosporins into Potent One against Resistant Clinical Uro-Pathogens via Gold Nanoparticles (2023).
115 -
Tailoring of Novel Bile Salt Stabilized Vesicles for Enhanced Transdermal Delivery of Simvastatin: A New Therapeutic Approach against Inflammation (2023).
116 -
The flavonoid hesperidin methyl chalcone as a potential therapeutic agent for cancer therapy: Molecular docking, in vitro cytotoxicity, and in vivo antitumor activity (2023).
117 -
Optimization of Potential Nanoemulgels for Boosting Transdermal Glimepiride Delivery and Upgrading Its Anti-Diabetic Activity (2023).
118 -
Anticancer potentials of metformin loaded coconut oil nanoemulsion on MCF-7, HepG2 and HCT-116 cell lines (2023).
119 -
Numerical optimization of Lenalidomide immunomodulatory drug inside the supercritical carbon dioxide system using different machine learning models (2024).
120 -
Cytotoxic Potential of Clarithromycin-Loaded Pumpkin Seed Oil-Based Nanoemulsion on Human Breast, Hepatic and Colorectal Cancer Cells (2023).
121 -
Development of Carvedilol Nanoformulation-Loaded Poloxamer-Based In Situ Gel for the Management of Glaucoma (2023).
122 -
Dual targeting multiwalled carbon nanotubes for improved neratinib delivery in breast cancer (2023).
123 -
Formulation optimization, in vitro and in vivo evaluation of niosomal nanocarriers for enhanced topical delivery of cetirizine (2023).
124 -
In Vitro Cytotoxicity and In Vivo Antitumor Activity of Lipid Nanocapsules Loaded with Novel Pyridine Derivatives (2023).
125 -
Nano-Formulating Besifloxacin and Employing Quercetin as a Synergizer to Enhance the Potency of Besifloxacin against Pathogenic Bacterial Strains: A Nano-Synergistic Approach (2023).
126 -
Ocular Delivery of Bimatoprost-Loaded Solid Lipid Nanoparticles for Effective Management of Glaucoma (2023).
127 -
Piperine-Loaded In Situ Gel: Formulation, In Vitro Characterization, and Clinical Evaluation against Periodontitis (2023).
128 -
The Anti-Virulence Activities of the Antihypertensive Drug Propranolol in Light of Its Anti-Quorum Sensing Effects against Pseudomonas aeruginosa and Serratia marcescens (2023).
129 -
Tailoring of Bilosomal Nanogel for Augmenting the Off-Label Use of Sildenafil Citrate in Pediatric Pulmonary Hypertension (2024).
130 -
Spanlastic-laden nanogel as a plausible platform for dermal delivery of bimatoprost with superior cutaneous deposition and hair regrowth efficiency in androgenic alopecia (2024).
131 -
Bacteriophage resurrection: Innovative impacts in medicine, biotechnology, and environmental solutions (2024).
Research Area
rug Formulation, Cancer Therapy, Gene Therapy, PEGylation, Liposomal delivery systems
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