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Curriculum Vitae

Kamel Abdelrehem Metwaly Bayomy

Faculty pharmacy - Department Medicinal Chemistry Department
NULL

BSc In NULL, [1990]
MSc In NULL, [1995]
(لا يوجد)
PhD In NULL, [1998]
(لا يوجد)

قائم باجازة خاصة

Academic Jobs

معيد : 22/9/1990
Doctor Assisant : 9/3/1995
Doctor : 24/11/1998
Professor Assisant : 12/9/2007
Professor : 27/3/2018

Publications

1 - Targeting methionyl tRNA synthetase: design, synthesis and antibacterial activity against Clostridium difficile of novel 3-biaryl-N-benzylpropan-1-amine derivatives (2016).

2 - Targeting methionyl t RNA synthetase: design ,synthesis and antibacterial activity against clostridium difficile of novel 3-biaryl-N-benzylpropan-1-amine derivatives (2016).

3 - Spiperone: influence of spiro ring substituents on 5-HT2A serotonin receptor binding (1998).

4 - Ketanserin and spiperone as templates for novel serotonin 5-HT2A antagonists (2002).

5 - Hydrazones of 2-arylquinoline-4-carboxylic acid hydrazides: synthesis and preliminary evaluation as antimicrobial agents (2006).

6 - Non-carboxylic analogues of aryl-propionic acids: synthesis, anti-inflammatory activity and ulcerogenic potential (2007).

7 - Pyrimido[4,5-c]quinolin-1(2H)-ones as a novel class of antimitotic agents: synthesis and in vitro cytotoxic activity (2007).

8 - Synthesis and biological activity of 2,5-diaryl-3-methyl-pyrimidino[4,5-c]quinolin-1(2H)-one derivatives (2007).

9 - . Synthesis, in-vitro Cytotoxicity, and a Preliminary Structure-Activity Relationship Investigation of Pyrimido[4,5-c]quinolin-1(2H)-ones (2010).

10 - Structure-activity relationship investigation of methoxy substitution on anticancer pyrimido[4,5-c]quinolin-1(2H)-ones (2013).

11 - The antimitotic pyrimido[4,5-c]quinolin-1(2H)-one scaffold: probing substituents at position 3 (2015).

12 - 1,3,4-Oxadiazole-2-thione derivatives; novel approach for anticancer and tubulin polymerization inhibitory activities (2016).

13 - Targeting methionyl tRNA synthetase: design, synthesis and antibacterial activity against Clostridium difficile of novel 3-biaryl-N-benzylpropan-1-amine derivatives (2016).

14 - Adenine and benzimidazole-based mimics of REP-3123 as antibacterial agents against Clostridium difficile and Bacillus anthracis: Design, synthesis and biological evaluation (2016).

15 - Novel 2,4- thiazolidinediones: synthesis, in vitro cytotoxic activity, and mechanistic investigation (2017).

16 - Novel quinazolinone-based 2,4-thiazolidinedione-3-acetic acid derivatives as potent aldose reductase inhibitors (2017).

17 - Quinazolinone-based rhodanine-3-acetic acids as potent aldose reductase inhibitors: synthesis, functional evaluation and molecular modeling study (2017).

18 - Synthesis and anticancer activity of novel quinazolinone-based rhodanines (2017).

19 - Quinazolinone-based rhodanine-3-acetic acids as potent aldose reductase inhibitors: Synthesis, functional evaluation and molecular modeling study (2017).

20 - Synthesis and anticancer activity of novel quinazolinone‑based rhodanines (2017).

21 - Design, synthesis, structure-activity relationships and X-ray structural studies of novel 1-oxopyrimido[4,5-c]quinoline-2-acetic acid derivatives as selective and potent inhibitors of human aldose reductase. (2018).

22 - Design, synthesis, structure-activity relationships and X-ray structural studies of novel 1-oxopyrimido[4,5-c]quinoline-2-acetic acid derivatives as selective and potent inhibitors of human aldose reductase. (2018).

23 - Inhibitors of aldehyde dehydrogenases of the 1A subfamily as putative anticancer agents: Kinetic characterization and effect on human cancer cells (2019).

24 - A novel scaffold to fight Pseudomonas aeruginosa pyocyanin production: early steps to novel antivirulence drugs (2020).

25 - 2-Hydroxyimino-6-aza-pyrimidine nucleosides: synthesis, DFT calculations, and antiviral evaluations (2020).

26 - 2-Hydroxyimino-6-aza-pyrimidine nucleosides: synthesis, DFT calculations, and antiviral evaluations† (2020).

27 - Design and synthesis of novel quinazolinone–chalcone hybrids as potential apoptotic candidates targeting caspase-3 and PARP-1: in vitro, molecular docking, and SAR studies (2022).

28 - Adenine and benzimidazole-based mimics of REP-3123 as antibacterial agents against Clostridium difficile and Bacillus anthracis: design, synthesis and biological evaluation (2016).

Research Area