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اشرف صبرى عبدالفتاح السيد

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Curriculum Vitae

Ashraf Sabry Abdelfattah alsaied

Faculty Science - Department Botany Department
NULL

Scientific degrees

BSc In NULL, [2001]
MSc In NULL, [2005]
(Studies on some heat-loving fungus and analyst of chitin)
PhD In NULL, [2008]
(Studies on some fungi producing antineoplastic agents)

الحالة الوظيفية الحالية :

قائم بالعمل

Academic Jobs

معيد : 26/11/2001
Doctor Assisant : 2/2/2006
Doctor : 27/5/2008
Professor Assisant : 28/5/2013
Professor : 25/7/2018

Publications

1 - Characterization of Homocysteine γ-Lyase from Submerged and Solid Cultures of Aspergillus fumigatus ASH (JX006238) (2013).

2 - Purification and Characterization of LAmino Acid Oxidase from the SolidState Grown Cultures of Aspergillus oryzae ASH1 (2013).

3 - Microbial L-methioninase: production, molecular characterization, and therapeutic applications (2010).

4 - Characterization and immobilization of purified Aspergillus flavipes L-methioninase: continuous production of methanethiol (2011).

5 - L-methioninase production by Aspergillus flavipes under solid-state fermentation (2009).

6 - L-Methioninase Production by Filamentous Fungi: I-Screening and Optimization Under Submerged Conditions (2009).

7 - L-glutaminase production by Trichoderma koningii under solid state fermentation (2008).

8 - L-Amino Acid Oxidase from Filamentous Fungi: Screening and Optimization. (2012).

9 - Pharmacokinetics, immunogenicity and anticancer efficiency of Aspergillus flavipes l-methioninase (2012).

10 - Enzymatic synthesis of c-glutamylglutamine, a stable glutamine analogue, by c-glutamyltranspeptidase from Escherichia coli K-12 (2010).

11 - Co-immobilization of PEGylated Aspergillus flavipes l-methioninase with glutamate dehydrogenase: A novel catalytically stable anticancer consortium (2014).

12 - Purification and immobilization of l-arginase from thermotolerant Penicillium chrysogenum KJ185377.1; with unique kinetic properties as thermostable anticancer enzyme (2015).

13 - Screening, morphological and molecular characterization of fungi producing cystathionine γ-lyase (2015).

14 - Biochemical and Pharmacokinetic Properties of PEGylated Cystathionine γ-Lyase from Aspergillus carneus KF723837 (2015).

15 - Purification, immobilization, and biochemical characterization of l-arginine deiminase from thermophilic Aspergillus fumigatus KJ434941: Anticancer activity in vitro (2015).

16 - Characterization of Glutathione-Homocystine Transhydrogenase as a Novel Isoform of Glutathione S-Transferase from Aspergillus flavipes (2015).

17 - Ex vivo application of secreated metabolites produced by soil inhabiting Bacillus spp. efficiently control foliar diseases caused by Alternaria spp (2016).

18 - Transcriptional and Proteomic Profiling of Aspergillus flavipes in Response to Sulfur Starvation (2015).

19 - Soluble and Volatile Metabolites of Plant Growth-Promoting Rhizobacteria (PGPRs): Role and Practical Applications in Inhibiting Pathogens and Activating Induced Systemic Resistance (ISR) (2015).

20 - Biochemical stability and molecular dynamic characterization of Aspergillus fumigatus cystathionine γ-lyase in response to various reaction effectors (2015).

21 - Characterization of Phytophthora spp. Isolated from Ornamental Plants in Florida (2016).

22 - Molecular cloning, biochemical characterization, and antitumor properties of a novel L-asparaginase from Synechococcus elongatus PCC6803 (2016).

23 - Aspergillus flavipes methionine γ-lyase-dextran conjugates with enhanced structural, proteolytic stability and anticancer efficiency (2017).

24 - Molecular and Spectroscopic Characterization of Aspergillus flavipes and Pseudomonas putida L-Methionine γ-Lyase in Vitro (2017).

25 - Genome editing approaches: manipulating of lovastatin and taxol synthesis of filamentous fungi by CRISPR/Cas9 system (2017).

26 - A highly efficient ligation-independent cloning system for CRISPR/Cas9 based genome editing in plants (2017).

27 - 1- LP-Dependent Enzymes: A potent therapeutic Approach for Cancer and Cardio-vascular Diseases. , ISBN 978-953-307-540-2. . (2011).

28 - Soluble and Volatile Metabolites of Plant Growth-Promoting Rhizobacteria (PGPRs): Role and Practical Applications in Inhibiting Pathogens and Activating Induced Systemic Resistance (ISR) (2015).

29 - Immobilization and Characterization of Purified Aspergillus flavus Peroxidase Mediated Silver Nanoparticle Synthesis: Peroxidase surface reactive residues are implemented for reduction of silver ions, more than its active sites (2017).

30 - A glucanolytic Pseudomonas sp. associated with Smilax bona-nox L. displays strong activity against Phytophthora parasitica. (2018).

31 - Sterol inhibitor “Fluconazole” enhance the Taxol yield and molecular expression of its encoding genes cluster from Aspergillus flavipes (2019).

32 - Induction of Taxol biosynthesis by Aspergillus terreus, endophyte of Podocarpus gracilior Pilger, upon intimate interaction with the plant endogenous microbes (2018).

33 - Biosynthesis and comparative bactericidal activity of silver nanoparticles synthesized by Aspergillus flavus and Penicillium crustosumagainst the multidrug-resistant bacteria (2018).

34 - Detection of aflatoxins by HPLC and the expression of biosynthetic nor-1 gene of aflatoxin and ocrA gene of ochratoxin. (2015).

35 - Molecular cloning, biochemical characterization, and antitumor properties of a novel L-asparaginase from Synechococcus elongatus PCC6803 (2016).

36 - Biochemical characterization of peptidylarginine deiminase-like orthologs from thermotolerant Emericella dentata and Aspergillus nidulans (2019).

37 - Comparative cytotoxic and anticancer effect of Taxol derived from Aspergillus terreus and Taxus brevifolia (2019).

38 - Biochemical and Metabolic Implications of Tricarboxylic Acids and their Transporters (2019).

39 - Purification and Characterization of Ornithine Decarboxylase from Aspergillus terreus; Kinetics of Inhibition by Various Inhibitors (2019).

40 - Restoring the Taxol biosynthetic machinery of Aspergillus terreus by Podocarpus gracilior Pilger microbiome, with retrieving the ribosome biogenesis proteins of WD40 superfamily (2019).

41 - Aspergillus nidulans thermostable arginine deiminase-Dextran conjugates with enhanced molecular stability, proteolytic resistance, pharmacokinetic properties and anticancer activity (2019).

42 - Production and Characterization of Taxol as Anticancer Agent from Aspergillus terreus (2019).

43 - Purification and Characterization of Anabaena flos-aquae Phenylalanine Ammonia-Lyase as a Novel Approach for Myristicin Biotransformation (2020).

44 - Detection, Purification and Elucidation of Chemical Structure and Antiproliferative Activity of Taxol Produced by PENICILLIUM CHRYSOGENUM (2020).

45 - Efficient biocontrol of Spodoptera littoralis by Aspergillus nidulans, an endophyte of Lantana camara (2020).

46 - Potential insecticidal activity of Sarocladium strictum, an endophyte of Cynanchum acutum, against Spodoptera littoralis, a polyphagous insect pest (2020).

47 - Aspergillus flavipes is a novel efficient biocontrol agent of Phytophthora parasitica (2020).

48 - Bioremediation and tolerance of zinc ions using Fusarium solani (2020).

49 - Tolerance and mycoremediation of silver ions by Fusarium solani (2020).

50 - Biocidal Activity of Metal Nanoparticles Synthesized by Fusarium solani against Multidrug-Resistant Bacteria and Mycotoxigenic Fungi (2020).

51 - Exploiting the Biosynthetic Potency of Taxol from Fungal Endophytes of Conifers Plants; Genome Mining and Metabolic Manipulation (2020).

52 - Conjugation of Aspergillus flavipes Taxol with Porphyrin Increases the Anticancer Activity of Taxol and Ameliorates Its Cytotoxic Eects (2020).

53 - Usage of pharmaceutical contraceptive drug for controlling Eobania vermiculata snails by baits technique (2020).

54 - Production and bioprocess optimization of antitumor Epothilone B analogue from Aspergillus fumigatus, endophyte of Catharanthus roseus, with response surface methodology (2021).

55 - Bioprocess optimization of glutathione production by Saccharomyces boulardii: biochemical characterization of glutathione peroxidase (2021).

56 - Biosystematic studies of some Egyptian species of Cestrum (Solanaceae) (2021).

57 - Biosystematic Study on Some Egyptian Species of Astragalus L. (Fabaceae) (2021).

58 - Production, bioprocess optimization and anticancer activity of Camptothecin from Aspergillus terreus and Aspergillus flavus, endophytes of Ficus elastica (2021).

59 - Exploration of microbiome of medicinally important plants as biocontrol agents against Phytophthora parasitica (2021).

60 - Biochemical Properties of Tyrosinase from Aspergillus terreus and Penicillium copticola; Undecanoic Acid from Aspergillus flavus, an Endophyte of Moringa oleifera, Is a Novel Potent Tyrosinase Inhibitor (2021).

61 - Biosynthesis and Anti-Mycotoxigenic Activity of Zingiber officinale Roscoe-Derived Metal Nanoparticles (2021).

62 - Purification and Biochemical Characterization of Taxadiene Synthase from Bacillus koreensis and Stenotrophomonas maltophilia (2021).

63 - Synthesis, In Silico Prediction and In Vitro Evaluation of Antimicrobial Activity, DFT Calculation and Theoretical Investigation of Novel Xanthines and Uracil Containing Imidazolone Derivatives (2021).

64 - Production, bioprocess optimization and g-irradiation of Penicillium polonicum, as a new Taxol producing endophyte from Ginko biloba (2021).

65 - Triggering the biosynthetic machinery of Taxol by Aspergillus flavipes via cocultivation with Bacillus subtilis: proteomic analyses emphasize the chromatin remodeling upon fungal-bacterial interaction (2021).

66 - Microbial Tyrosinase: Biochemical, Molecular Properties and Pharmaceutical Applications (2021).

67 - Evaluation of Phytochemical Screening and Antifungal Activity for Some Annual Plant Extracts in Egypt (2021).

68 - Purification and Characterization of Thermostable Cytosine Deaminase from Aspergillus fumigatus (2021).

69 - Evaluation of the Curative and Protective Role of Fresh Chicory Juice in Treatment of Hepatic Fibrosis in Male Albino Rats (2021).

70 - Differential Modulatory Effect of Epigallocatechin-3-gallate in Suppression of Tumor Proliferation (2021).

71 - Recent Development in Bioactive Peptides from Plant and Animal Products and Their Impact on the Human Health (2021).

72 - Thermostable Chitosan-L-Asparaginase conjugate from Aspergillus fumigatus is a novel structurally stable composite for abolishing acrylamide formation in French fried potatoes (2022).

73 - Biosorption removal of iron from water by Aspergillus niger (2022).

74 - Bioprocesses optimization and anticancer activity of camptothecin from Aspergillus flavus, an endophyte of in vitro cultured Astragalus fruticosus (2022).

75 - Microbial cytosine deaminase is a programmable anticancer prodrug mediating enzyme: antibody, and gene directed enzyme prodrug therapy (2022).

76 - Fungal biopriming increases the resistance of wheat to abiotic stress (2022).

77 - In vitro Micropropagation, Biological Activities and Phenolic Profile of Astragalus fruticosus Forssk (2022).

78 - Molecular and metabolic traits of some Egyptian species of Cassia L. and Senna Mill (Fabaceae‑Caesalpinioideae) (2022).

79 - Production, Bioprocessing and Anti-Proliferative Activity of Camptothecin from Penicillium chrysogenum, “An Endozoic of Marine Sponge, Cliona sp.”, as a Metabolically Stable Camptothecin Producing Isolate (2022).

80 - Boosting the Anticancer Activity of Aspergillus flavus “endophyte of Jojoba” Taxol via Conjugation with Gold Nanoparticles Mediated by γ‑Irradiation (2022).

81 - Aspergillus Niger thermostable Cytosine deaminase‑dextran conjugates with enhanced structure stability, proteolytic resistance, and Antiproliferative activity (2023).

82 - Production and bioprocessing of camptothecin from Aspergillus terreus, an endophyte of Cestrum parqui, restoring their biosynthetic potency by Citrus limonum peel extracts (2023).

83 - Recent Development in Bioactive Peptides from Plant and Animal Products and Their Impact on the Human Health0 (2022).

84 - Aspergillus terreus camptothecin‑sodium alginate/titanium dioxide nanoparticles as a novel nanocomposite with enhanced compatibility and anticancer efficiency in vivo (2023).

85 - Aspergillus terreus camptothecin‑sodium alginate/titanium dioxide nanoparticles as a novel nanocomposite with enhanced compatibility and anticancer efficiency in vivo (2023).

86 - Production, bioprocessing and antiproliferative activity of camptothecin from Aspergillus terreus, endophyte of Cinnamomum camphora: restoring their biosynthesis by indigenous microbiome of C. camphora (2023).

87 - Distinguishing features of Lycium L. species (family Solanaceae) distributed in Egypt based on their anatomical, metabolic, molecular, and ecological characteristics (2023).

88 - Phytochemical and metabolic profiling of the different Podocarpus species in Egypt: Potential antimicrobial and antiproliferative activities (2023).

89 - Biochemical, molecular and anti-tumor characterization of L-methionine gamma lyase produced by local Pseudomonas sp. in Egypt (2023).

90 - Physiological and metabolic traits of Taxol biosynthesis of endophytic fungi inhabiting plants: Plant-microbial crosstalk, and epigenetic regulators (2023).

91 - Proteomics and metabolomics analyses of camptothecin-producing Aspergillus terreus reveal the integration of PH domain-containing proteins and peptidylprolyl cis/trans isomerase in restoring the camptothecin biosynthesis (2023).

92 - Biochemical Characterization of Thermostable Acrylamide Amidohydrolase from Aspergillus fumigatus with Potential Activity for Acrylamide Degradation in Various Food Products (2024).

93 - Camptothecin bioprocessing from Aspergillus terreus, an endophyte of Catharanthus roseus: antiproliferative activity, topoisomerase inhibition and cell cycle analysis (2024).

94 - Bioprocessing of Epothilone B from Aspergillus fumigatus under solid state fermentation: Antiproliferative activity, tubulin polymerization and cell cycle analysis (2024).

95 - Production and bioprocessing of Taxol from Aspergillus niger, an endophyte of Encephalartos whitelockii, with a plausible biosynthetic stability: antiproliferative activity and cell cycle analysis (2024).

96 - Biochemical, molecular and anti-tumor characterization of L-methionine gamma lyase produced by local Pseudomonas sp. in Egypt (2023).

Research Area